Coupling between beta band and high frequency oscillations as a clinically useful biomarker for DBS.

Coupling between beta band and high frequency oscillations as a clinically useful biomarker for DBS.

Publication date: Feb 21, 2024

Beta hypersynchrony was recently introduced into clinical practice in Parkinson’s disease (PD) to identify the best stimulation contacts and for adaptive deep brain stimulation (aDBS) sensing. However, many other oscillopathies accompany the disease, and beta power sensing may not be optimal for all patients. The aim of this work was to study the potential clinical usefulness of beta power phase-amplitude coupling (PAC) with high frequency oscillations (HFOs). Subthalamic nucleus (STN) local field potentials (LFPs) from externalized DBS electrodes were recorded and analyzed in PD patients (n = 19). Beta power and HFOs were evaluated in a resting-state condition; PAC was then studied and compared with the electrode contact positions, structural connectivity, and medication state. Beta-HFO PAC (mainly in the 200-500 Hz range) was observed in all subjects. PAC was detectable more specifically in the motor part of the STN compared to beta power and HFOs. Moreover, the presence of PAC better corresponds to the stimulation setup based on the clinical effect. PAC is also sensitive to the laterality of symptoms and dopaminergic therapy, where the greater PAC cluster reflects the more affected side and medication “off” state. Coupling between beta power and HFOs is known to be a correlate of the PD “off” state. Beta-HFO PAC seems to be more sensitive than beta power itself and could be more helpful in the selection of the best clinical stimulation contact and probably also as a potential future input signal for aDBS.

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Concepts Keywords
500hz Beta
Biomarker Clinical
Helpful Compared
Parkinsons Coupling
Therapy Dbs
Frequency
Hfos
High
Oscillations
Pac
Potential
Sensing
State
Stimulation
Stn

Semantics

Type Source Name
drug DRUGBANK Albendazole
disease MESH Parkinson’s disease
drug DRUGBANK Tropicamide
drug DRUGBANK Trihexyphenidyl
drug DRUGBANK Profenamine
disease MESH gait
drug DRUGBANK Esomeprazole
drug DRUGBANK L-Phenylalanine
drug DRUGBANK Levodopa
disease MESH sti
disease MESH dementia
drug DRUGBANK Aspartame
pathway KEGG Parkinson disease
drug DRUGBANK Coenzyme M
pathway REACTOME Reproduction

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