The potential roles of salivary biomarkers in neurodegenerative diseases.

The potential roles of salivary biomarkers in neurodegenerative diseases.

Publication date: Feb 19, 2024

Current research efforts on neurodegenerative diseases are focused on identifying novel and reliable biomarkers for early diagnosis and insight into disease progression. Salivary analysis is gaining increasing interest as a promising source of biomarkers and matrices for measuring neurodegenerative diseases. Saliva collection offers multiple advantages over the currently detected biofluids as it is easily accessible, non-invasive, and repeatable, allowing early diagnosis and timely treatment of the diseases. Here, we review the existing findings on salivary biomarkers and address the potential value in diagnosing neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and Amyotrophic lateral sclerosis. Based on the available research, β-amyloid, tau protein, α-synuclein, DJ-1, Huntington protein in saliva profiles display reliability and validity as the biomarkers of neurodegenerative diseases.

Concepts Keywords
Alzheimer Amyotrophic lateral sclerosis
Amyloid Huntington’s disease
Biomarkers Neurodegenerative diseases
Dj Salivary biomarkers


Type Source Name
disease MESH neurodegenerative diseases
pathway REACTOME Neurodegenerative Diseases
disease MESH disease progression
disease MESH Alzheimer’s disease
disease MESH Parkinson’s disease
disease MESH Huntington’s disease
disease MESH Amyotrophic lateral sclerosis
pathway KEGG Amyotrophic lateral sclerosis

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