Publication date: Jun 18, 2024

Patients with Lewy body diseases have an increased risk of dementia, which is a significant predictor for survival. Posterior cortical hypometabolism on [F]fluorodeoxyglucose positron emission tomography (PET) precedes the development of dementia by years. We therefore examined the prognostic value of cerebral glucose metabolism for survival. We enrolled patients diagnosed with Parkinson’s disease (PD), Parkinson’s disease with dementia, or dementia with Lewy bodies who underwent [F]fluorodeoxyglucose PET. Regional cerebral metabolism of each patient was analyzed by determining the expression of the PD-related cognitive pattern (Z-score) and by visual PET rating. We analyzed the predictive value of PET for overall survival using Cox regression analyses (age- and sex-corrected) and calculated prognostic indices for the best model. Glucose metabolism was a significant predictor of survival in 259 included patients (n = 118 events; hazard ratio: 1. 4 [1. 2-1. 6] per Z-score; hazard ratio: 1. 8 [1. 5-2. 2] per visual PET rating score; both p 

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