Risk Factors of Multi-Drug Resistant Tuberculosis among Tuberculosis Patients in Province 3, Nepal: A case-control study

Publication date: Jun 17, 2024

Background Drug-resistant tuberculosis poses a significant threat to global TB control efforts, potentially reversing progress made in reducing TB-related morbidity and mortality. This study aims to identify risk factors for multidrug-resistant TB [MDR-TB] in Province 3, Nepal. Methodology A case-control study was conducted by matching TB-infected patients undergoing MDR-TB treatment and DS-TB treatment by gender. Data was collected through structured questionnaires and interviews and analyzed using binary logistic regression. Results Significant risk factors for MDR-TB included Pulmonary Tuberculosis [PTB], previous TB treatment history, close contact with DR-TB patients, and subjective feelings of sadness. Conclusion The study highlights the importance of prevention measures to break transmission chains and infection control in health facilities. Additionally, it underscores the need for mental health support for TB patients.

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Concepts	Keywords
Costlier	Certified
Interviews	Control
Nepal	Controls
Tuberculosis	Drug
	Factors
	Higher
	Mdr
	Medrxiv
	Nepal
	Peer
	Preprint
	Resistant
	Risk
	Treatment
	Tuberculosis

Semantics

Type	Source	Name
disease	MESH	Multi-Drug Resistant Tuberculosis
disease	MESH	Tuberculosis
pathway	KEGG	Tuberculosis
disease	MESH	morbidity
disease	MESH	Pulmonary Tuberculosis
disease	MESH	infection
drug	DRUGBANK	Coenzyme M
disease	MESH	death
disease	MESH	AIDS
drug	DRUGBANK	Isoniazid
drug	DRUGBANK	Levofloxacin
drug	DRUGBANK	Pyrazinamide
drug	DRUGBANK	Rifampicin
disease	MESH	communicable diseases
drug	DRUGBANK	Spinosad
disease	MESH	COVID 19 pandemic
drug	DRUGBANK	Pentaerythritol tetranitrate
disease	MESH	Marital status
disease	MESH	complications
disease	MESH	treatment failure
drug	DRUGBANK	Ethanol
disease	MESH	social stigma