Publication date: Jun 19, 2024
To examine the correlation between serum insulin-like growth factor 1 (IGF-1) and osteoporosis (OP) in Parkinson’s disease (PD). We retrospectively analyzed clinical data from 105 PD patients (PD group) and 78 individuals in the health examination group (HC group). We compared general clinical data and serum IGF-1 levels between the two groups. PD patients were further categorized into PD with OP (50 cases) and PD without OP (55 cases) based on dual-energy X-ray absorptiometry (DXA) results for bone density. We compared general clinical data and serum IGF-1 levels between these two subgroups. Pearson correlation coefficient analysis was conducted to assess the relationship between serum IGF-1 levels and bone density at the lumbar spine and left femoral neck. Multifactorial logistic regression analysis was performed to identify risk factors for PD with OP. Serum IGF-1 levels were significantly lower in the PD group compared to the HC group (P
| Concepts | Keywords |
|---|---|
| Bone | Bone mineral density |
| Disease | IGF-1 |
| Insulin | Osteoporosis |
| Parkinson | Parkinson’s disease |
Semantics
| Type | Source | Name |
|---|---|---|
| drug | DRUGBANK | Mecasermin |
| disease | MESH | osteoporosis |
| disease | MESH | Parkinson’s disease |