Publication date: Jun 20, 2024

“Future studies can compare with our reference dataset to understand how a normal immune response to a new pathogen compares to a vaccine-induced immune response. We need to understand how factors like natural exposure to the disease affect the body’s response to the virus or a vaccine. “Shobana Balasingam, research lead in Wellcome’s Infectious Disease team, said, “Human challenge models are an invaluable way to build our understanding of how the body responds to infectious disease. This offers insights into immune cell communication and potential for developing targeted T cell therapies against not just COVID-19, but other diseases. Dr. Editors have highlighted the following attributes while ensuring the content’s credibility:Clinician administering virus through the nose, as part of UK COVID-19 Human Challenge study. “More information: Rik Lindeboom, Human SARS-CoV-2 challenge uncovers local and systemic response dynamics, Nature (2024). “These results are an exciting addition to our evidence-base of how different people might respond to, or be protected against, COVID-19 infections.

Semantics