Long-COVID impacts taste and olfactory in individuals with substance use disorder: A retrospective cohort study from the TriNetX US Collaborative Networks.

Long-COVID impacts taste and olfactory in individuals with substance use disorder: A retrospective cohort study from the TriNetX US Collaborative Networks.

Publication date: Jul 01, 2024

Substance use disorder (SUD) exacerbates the impact of Long-COVID, particularly increasing the risk of taste and olfactory disorders. Analyzing retrospective cohort data from TriNetX and over 33 million records (Jan 2020-Dec 2022), this study focused on 1,512,358 participants, revealing that SUD significantly heightens the likelihood of experiencing taste disturbances and anosmia in Long-COVID sufferers. Results indicated that individuals with SUD face a higher incidence of sensory impairments compared to controls, with older adults and women being particularly vulnerable. Smokers with SUD were found to have an increased risk of olfactory and taste dysfunctions. The findings underscore the importance of early screening, diagnosis, and interventions for Long-COVID patients with a history of SUD, suggesting a need for clinicians to monitor for depression and anxiety linked to sensory dysfunction for comprehensive care.

Concepts Keywords
Increasing Adult
Psychiatry Aged
Taste Alcohol
Anosmia
COVID-19
Drug abuse
Female
Humans
Male
Middle Aged
Olfaction Disorders
Opioids
Post-Acute COVID-19 Syndrome
Retrospective Studies
Smell
Smoker
Substance-Related Disorders
Taste Disorders
United States
Young Adult

Semantics

Type Source Name
disease MESH substance use disorder
disease IDO history
disease MESH Long Covid
drug DRUGBANK Ethanol
disease MESH COVID-19
disease MESH Olfaction Disorders
disease MESH Taste Disorders

Original Article

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