DNA tetrahedral nanocages as a promising nanocarrier for dopamine delivery in neurological disorders.

Publication date: Aug 02, 2024

Dopamine is a neurotransmitter in the central nervous system that is essential for many bodily and mental processes, and a lack of it can cause Parkinson’s disease. DNA tetrahedral (TD) nanocages are promising in bio-nanotechnology, especially as a nanocarrier. TD is highly programmable, biocompatible, and capable of cell differentiation and proliferation. It also has tissue and blood-brain barrier permeability, making it a powerful tool that could overcome potential barriers in treating neurological disorders. In this study, we used DNA TD as a carrier for dopamine to cells and zebrafish embryos. We investigated the mechanism of complexation between TD and dopamine hydrochloride using gel electrophoresis, fluorescence and circular dichroism (CD) spectroscopy, atomic force microscopy (AFM), and molecular dynamic (MD) simulation tools. Further, we demonstrate that these dopamine-loaded DNA TD nanostructures enhanced cellular uptake and differentiation ability in SH-SY5Y neuroblastoma cells. Furthermore, we extended the study to zebrafish embryos as a model organism to examine survival and uptake. The research provides valuable insights into the complexation mechanism and cellular uptake of dopamine-loaded DNA tetrahedral nanostructures, paving the way for further advancements in nanomedicine for Parkinson’s disease and other neurological disorders.

Concepts Keywords
Nanotechnology Complexation
Nervous Differentiation
Parkinson Disorders
Td Dopamine
Zebrafish Embryos
Loaded
Mechanism
Nanocages
Nanocarrier
Neurological
Parkinson
Promising
Tetrahedral
Uptake
Zebrafish

Semantics

Type Source Name
drug DRUGBANK Dopamine
disease MESH neurological disorders
disease MESH Parkinson’s disease
disease MESH neuroblastoma

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