Construction and validation of a risk model of proteinuria in patients with omicron COVID-19: retrospective cohort study.

Publication date: Dec 01, 2024

To explore the risk factors of proteinuria in Omicron variant patients and to construct and verify the risk predictive model. 1091 Omicron patients who were hospitalized from August 2022 to November 2022 at Tianjin First Central Hospital were defined as the derivation cohort. 306 Omicron patients who were hospitalized from January 2022 to March 2022 at the same hospital were defined as the validation cohort. The risk factors of proteinuria in derivation cohort were screened by univariate and multivariate logistic regression analysis, and proteinuria predicting scoring system was constructed and the receiver operating characteristic(ROC)curve was drawn to test the prediction ability. The proteinuria risk model was externally validated in validation cohort. 7 factors including comorbidities, blood urea nitrogen (BUN), serum sodium (Na), uric acid (UA), C reactive protein (CRP) and vaccine dosages were included to construct a risk predictive model. The score ranged from -5 to 16. The area under the ROC curve(AUC) of the model was 0. 8326(95% CI 0. 7816 to 0. 8835, p 

Concepts Keywords
August Adult
Hospitalized Aged
November China
Proteinuria COVID-19
Female
Humans
Male
Middle Aged
omicron
Proteinuria
Proteinuria
Retrospective Studies
Risk Assessment
Risk Factors
risk factors
risk model
ROC Curve
SARS-CoV-2

Semantics

Type Source Name
disease MESH proteinuria
disease MESH COVID-19
drug DRUGBANK Saquinavir
disease IDO blood
drug DRUGBANK Urea
drug DRUGBANK Nitrogen
drug DRUGBANK Uric Acid
disease VO vaccine

Original Article

(Visited 1 times, 1 visits today)

Leave a Comment

Your email address will not be published. Required fields are marked *