Microbiota-gut-brain axis in perioperative neurocognitive and depressive disorders: Pathogenesis to treatment.

Publication date: Aug 05, 2024

An increasing number of people undergo anesthesia and surgery. Perioperative neurocognitive and depressive disorders are common central nervous system complications with similar pathogeneses. These conditions pose a deleterious threat to human health and a significant societal burden. In recent years, numerous studies have focused on the role of the gut microbiota and its metabolites in the central nervous system via the gut-brain axis. Its involvement in perioperative neurocognitive and depressive disorders has attracted considerable attention. This review aimed to elucidate the role of the gut microbiota and its metabolites in the pathogenesis of perioperative neurocognitive and depressive disorders, as well as the value of targeted interventions and treatments.

Concepts Keywords
Depressive Depression
Increasing Microbiota-gut-brain axis
Neurocognitive Neurocognitive disorder
Pathogeneses Perioperative
Surgery

Semantics

Type Source Name
disease MESH depressive disorders
disease MESH Pathogenesis
disease MESH complications
disease MESH Neurocognitive disorder

Original Article

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