Association of COVID-19 vaccination and anxiety symptoms: A Scleroderma Patient-centered Intervention Network (SPIN) Cohort longitudinal study.

Publication date: Sep 01, 2024

Symptoms of anxiety increased early in the COVID-19 pandemic among people with systemic sclerosis (SSc) then returned to pre-pandemic levels, but this was an aggregate finding and did not evaluate whether vaccination may have contributed to reduced anxiety symptom levels. We investigated whether being vaccinated for COVID-19 was associated with reduced anxiety symptoms among people with SSc. The longitudinal Scleroderma Patient-centered Intervention Network (SPIN) COVID-19 Cohort was launched in April 2020 and included participants from the ongoing SPIN Cohort and external enrollees. Participants completed measures bi-weekly through July 2020, then every 4 weeks afterwards through August 2022 (32 assessments). We used linear mixed models to evaluate longitudinal trends of PROMIS Anxiety 4a v1. 0 anxiety domain scores and their association with vaccination. Among 517 participants included in analyses, 489 (95%) were vaccinated by September 2021, and no participants were vaccinated subsequently. Except for briefly at the beginning, when few had received a vaccine, and end, when only 28 participants remained unvaccinated, anxiety symptom trajectories were largely overlapping. Participants who were never vaccinated had higher anxiety symptoms by August 2022, but there were no other differences, and receiving a vaccination did not appear to change anxiety symptom trajectories meaningfully. Vaccination did not appear to influence changes in anxiety symptoms among vulnerable people with SSc during the COVID-19 pandemic. This may be due to people restricting their behavior when they were unvaccinated and returning to more normal social engagement once vaccinated to maintain a steady level of anxiety symptoms.

Concepts Keywords
4weeks Adult
July Aged
Sclerosis Anxiety
Vaccinated Anxiety
COVID-19
COVID-19
COVID-19 Vaccines
COVID-19 Vaccines
Female
Humans
Longitudinal Studies
Male
Middle Aged
Patient-Centered Care
SARS-CoV-2
Scleroderma
Scleroderma, Systemic
Systemic sclerosis
Vaccination
Vaccination

Semantics

Type Source Name
disease MESH COVID-19
disease VO vaccination
disease IDO intervention
disease MESH systemic sclerosis
disease IDO symptom
disease VO vaccinated
disease VO vaccine
disease VO unvaccinated

Original Article

(Visited 2 times, 1 visits today)

Leave a Comment

Your email address will not be published. Required fields are marked *