BMI is Associated with Post-Acute Elevations in Biomarkers of Platelet Activation and Inflammation in Unvaccinated Adults Diagnosed with COVID-19 in the Previous 8 Weeks.

Publication date: Aug 08, 2024

Obesity has arisen as a prominent risk factor for COVID-19 severity and Long COVID (LC), potentially owed in part to the obesity-induced proinflammatory state. This study aimed to examine relationships among circulating inflammatory biomarkers and BMI in nonhospitalized adults recently diagnosed with COVID-19. This analysis included participants who completed a randomized placebo-controlled trial conducted October 2020-March 2021. Participants (19-53y) were unvaccinated and enrolled following COVID-19 diagnosis as allowed by CDC return-to-work guidance. Anthropometrics and biomarkers were assessed at study baseline and week-four. We examined the associations between BMI and inflammatory biomarkers via multiple regression models. At study baseline, (i. e., the point of enrollment following COVID-19 diagnosis) across all participants (N=60) a higher BMI was associated with elevations in several inflammatory biomarkers including IL-6 (β=7. 63, 95%CI= 3. 54, 11. 89, p = 0. 0004), ferritin (β= 6. 31, 95%CI= 1. 97,10. 83, p=0. 0047), hsCRP (β= 13. 1, 95% CI=8. 03, 18. 42, p=

Concepts Keywords
Biomarkers Acute
Covid Adults
Obesity Baseline
October Biomarkers
Platelet Bmi
Ci=
Covid
Diagnosed
Diagnosis
Elevations
Inflammatory
Obesity
Participants
Post
Unvaccinated

Semantics

Type Source Name
pathway KEGG Platelet activation
disease MESH Inflammation
disease VO unvaccinated
disease MESH COVID-19
disease MESH Obesity
disease MESH Long COVID
disease MESH return-to-work

Original Article

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