Publication date: Aug 08, 2024
Obesity has arisen as a prominent risk factor for COVID-19 severity and Long COVID (LC), potentially owed in part to the obesity-induced proinflammatory state. This study aimed to examine relationships among circulating inflammatory biomarkers and BMI in nonhospitalized adults recently diagnosed with COVID-19. This analysis included participants who completed a randomized placebo-controlled trial conducted October 2020-March 2021. Participants (19-53y) were unvaccinated and enrolled following COVID-19 diagnosis as allowed by CDC return-to-work guidance. Anthropometrics and biomarkers were assessed at study baseline and week-four. We examined the associations between BMI and inflammatory biomarkers via multiple regression models. At study baseline, (i. e., the point of enrollment following COVID-19 diagnosis) across all participants (N=60) a higher BMI was associated with elevations in several inflammatory biomarkers including IL-6 (β=7. 63, 95%CI= 3. 54, 11. 89, p = 0. 0004), ferritin (β= 6. 31, 95%CI= 1. 97,10. 83, p=0. 0047), hsCRP (β= 13. 1, 95% CI=8. 03, 18. 42, p=
Concepts | Keywords |
---|---|
Biomarkers | Acute |
Covid | Adults |
Obesity | Baseline |
October | Biomarkers |
Platelet | Bmi |
Ci= | |
Covid | |
Diagnosed | |
Diagnosis | |
Elevations | |
Inflammatory | |
Obesity | |
Participants | |
Post | |
Unvaccinated |
Semantics
Type | Source | Name |
---|---|---|
pathway | KEGG | Platelet activation |
disease | MESH | Inflammation |
disease | VO | unvaccinated |
disease | MESH | COVID-19 |
disease | MESH | Obesity |
disease | MESH | Long COVID |
disease | MESH | return-to-work |