Repetitive Transcranial Magnetic Stimulation (rTMS) as an Early Intervention in Major Depression (MD) Compared to Antidepressant Selective Serotonin Reuptake Inhibitor (SSRI) Medication (Early-TMS)

Publication date: Aug 05, 2024

The aim of this randomized multicentre phase 2 clinical trial is to compare the effects of rTMS and SSRI medication as early treatment of depression. In this two-stage, therapy response-adapted trial, 106 patients suffering from non-treatment resistant major depression (non-TR MD) will be randomized in Stage I to either 4 weeks bilateral theta burst stimulation (TBS) or 4 weeks antidepressant SSRI medication. The allocation to Stage II occurs therapy response-adapted. Patients receive either a maintenance treatment or a switch to the respective other treatment arm. The primary outcome is the comparison of the two study arms with regard to therapy response measured with the Montgomery-Asberg Depression Rating Scale (MADRS) after 4 weeks at the end of Stage I.

Concepts Keywords
Benzodiazepines Depression
Mri non-invasive brain stimulation
Stage non-treatment resistant depression
Suicidal theta burst stimulation
Tbs

Semantics

Type Source Name
drug DRUGBANK Serotonin
drug DRUGBANK Tilmicosin
disease MESH suicidal ideation
drug DRUGBANK Lorazepam
disease MESH anxiety disorders
disease MESH personality disorder
disease MESH neoplasms brain
disease MESH stroke
disease MESH neurodegenerative diseases
disease MESH epilepsy
disease MESH epileptic seizures
disease MESH contraindications
drug DRUGBANK Escitalopram
disease MESH Major Depressive Disorder
disease MESH treatment resistant depression

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