Global burden of viral infectious diseases of poverty based on Global Burden of Diseases Study 2021.

Global burden of viral infectious diseases of poverty based on Global Burden of Diseases Study 2021.

Publication date: Oct 08, 2024

Viral infectious diseases of poverty (vIDPs) remain a significant global health challenge. Despite their profound impact, the burden of these diseases is not comprehensively quantified. This study aims to analyze the global burden of six major vIDPs, including coronavirus disease 2019 (COVID-19), HIV/AIDS, acute hepatitis, dengue, rabies, and Ebola virus disease (EVD), using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 (GBD 2021). Following the GBD 2021 framework, we analyzed the incidence, mortality, and disability-adjusted life years (DALYs) of the six vIDPs across 204 countries and territories from 1990 to 2021. We examined the association between the Socio-Demographic Index (SDI) and the burden of vIDPs. All estimates were reported as numbers and rates per 100,000 population, calculated using the Bayesian statistical model employed by GBD 2021, with 95% uncertainty intervals (UI). In 2021, vIDPs caused approximately 8. 7 million deaths and 259. 2 million DALYs, accounting for 12. 8% and 9. 0% of the global all-cause totals, respectively. Globally, the burden of vIDPs varied significantly: COVID-19 caused around 7. 9 million (95% UI: 7. 5, 8. 4) deaths and 212. 0 million (95% UI 197. 9, 234. 7) DALYs in 2021. Acute hepatitis had the second-highest age-standardized incidence rate, with 3411. 5 (95% UI: 3201. 8, 3631. 3) per 100,000 population, while HIV/AIDS had a high age-standardized prevalence rate, with 483. 1 (95% UI: 459. 0, 511. 4) per 100,000 population. Dengue incidence cases rose from 26. 5 million (95% UI: 3. 9, 51. 9) in 1990 to 59. 0 million (95% UI: 15. 5, 106. 9) in 2021. Rabies, although reduced in prevalence, continued to pose a significant mortality risk. EVD had the lowest overall burden but significant outbreak impacts. Age-standardized DALY rates for vIDPs were significantly negatively correlated with SDI: acute hepatitis (r = -0. 8, P 

Concepts Keywords
Accounting Disability-adjusted life years
Coronavirus Socio-Demographic Index
Poverty

Semantics

Type Source Name
disease MESH infectious diseases
disease MESH coronavirus disease 2019
disease MESH AIDS
disease MESH hepatitis
disease MESH dengue
disease MESH rabies
disease MESH Ebola virus disease
disease MESH uncertainty

Original Article

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