Publication date: Oct 09, 2024
Follicular dendritic cell sarcoma is a rare mesenchymal neoplasm arising from follicular dendritic cells (FDC) of lymphoid follicles. While the majority of FDC sarcoma cases arise within lymph nodes, approximately 30% manifest in extranodal sites. Only 4 prior occurrences of intra-parotid FDC sarcomas have been documented. We are reporting a rare case of FDC of the parotid gland in a 65-year-old male with a questionable history of B-cell lymphoma. The patient underwent a right total parotidectomy and bilateral neck dissection. A diagnosis of follicular dendritic cell (FDC) sarcoma was made, with one positive intra-parotid node. The malignant cells expressed the characteristic markers for FDC sarcoma but with positivity of the melanocytic marker PRAME. This is a case of FDC sarcoma with an unusual extranodal localization in the parotid gland. Immunohistochemistry was useful in making a diagnosis although the positivity for the melanocytic marker PRAME was unusual and unreported before.
| Concepts | Keywords |
|---|---|
| Immunohistochemistry | Follicular dendritic cells |
| Lymphoma | Melanoma |
| Parotidectomy | Parotid gland |
| Rare | PRAME |
| Sarcoma |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Follicular dendritic cell sarcoma |
| disease | MESH | neoplasm |
| disease | MESH | sarcoma |
| disease | MESH | B-cell lymphoma |
| disease | MESH | Melanoma |
| pathway | KEGG | Melanoma |