Publication date: Oct 09, 2024
SARS-CoV-2 virus infects cells by engaging with ACE2 requiring protease TMPRSS2. ACE2 is highly expressed in kidneys. Predictors for severe disease are high age and male sex. We hypothesized that ACE2 and TMPRSS2 proteins are more abundant (1) in males and with increasing age in kidney and (2) in urine and extracellular vesicles (EVs) from male patients with COVID-19 and (3) SARS-CoV-2 is present in urine and EVs during infection. Kidney cortex samples from patients subjected to cancer nephrectomy (male/female;
| Concepts | Keywords |
|---|---|
| Covid | Albuminuria |
| Kidneys | Angiotensin II |
| Males | Exosomes |
| Tmprss2 | Hypertension |
| Virus | Protease |
| SARS-CoV-2 |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | COVID-19 |
| disease | MESH | infection |
| disease | MESH | cancer |
| disease | MESH | Albuminuria |
| drug | DRUGBANK | Angiotensin II |
| disease | MESH | Hypertension |
Original Article
(Visited 2 times, 1 visits today)