Cubosomes and hexosomes stabilized by sorbitan monooleate as biocompatible nanoplatforms against skin metastatic human melanoma.

Cubosomes and hexosomes stabilized by sorbitan monooleate as biocompatible nanoplatforms against skin metastatic human melanoma.

Publication date: Jan 01, 2025

Nanoparticles have become versatile assets in the medical field, providing notable benefits across diverse medical arenas including controlled drug delivery, imaging, and immunological assays. Among these, non-lamellar lipid nanoparticles, notably cubosomes and hexosomes, showcase remarkable biocompatibility and stability, rendering them as optimal choices for theranostic applications. Particularly, incorporating edge activators like sodium taurocholate enhances the potential of these nanoparticles for dermal and transdermal drug delivery, overcoming the stratum corneum, a first line of defense in our skin. This study reports on the formulation of monoolein-based cubosomes and hexosomes incorporating taurocholate and stabilized by Span 80 and co-encapsulating Chlorin e6 and coenzyme QH for photodynamic therapy in skin metastatic melanoma. The formulations were optimized using small-angle X-ray scattering, and cryo-transmission electron microscopy confirmed the presence of cubosomes or hexosomes, depending on the ratio between taurocholate and Span 80. Furthermore, the co-loaded nanoparticles exhibited high encapsulation efficiencies for both Ce6 and the coenzyme QH. In vitro studies on human melanoma cells (Me45) demonstrated the biocompatibility and photodynamic activity of the loaded formulations. These findings show the possibility of formulating more biocompatible cubosomes and hexosomes for photodynamic therapy in skin cancer treatment.

Concepts Keywords
Biocompatibility Antineoplastic Agents
Cubosomes Antineoplastic Agents
Photodynamic Bile salts
Sodium Biocompatible Materials
Therapy Biocompatible Materials
Cell Line, Tumor
Cell Survival
Chlorophyllides
Chlorophyllides
Cubosomes
Cytotoxicity
Edge activators
Glycerides
Glycerides
Hexoses
Hexoses
Hexosomes
Humans
Melanoma
monoolein
Nanoparticles
Non-lamellar
Particle Size
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents
Photosensitizing Agents
phytochlorin
Porphyrins
Porphyrins
Skin Neoplasms
sorbitan monostearate
Stabilizer
Surface Properties
Taurocholic Acid
Taurocholic Acid
Ubiquinone
Ubiquinone

Semantics

Type Source Name
disease MESH melanoma
pathway KEGG Melanoma
drug DRUGBANK Glyceryl 1-oleate
disease MESH skin cancer
disease MESH Tumor
drug DRUGBANK Taurocholic Acid

Original Article

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