Publication date: Oct 14, 2024
In this study, the team conducted comprehensive metabolic examinations of hundreds of brain molecules to identify which are associated with motor activity in the absence of dopamine. Symptoms, which include tremors, shaking, and lack of movement, are caused by decreasing levels of dopamine in the brain as those neurons die. Remarkably, ophthalmic acid not only enabled movement, but also far surpassed L-dopa in sustaining positive effects. L-dopa, the front-line drug for treatment, acts by replacing the lost dopamine and has a duration of two to three hours.
| Concepts | Keywords |
|---|---|
| Biophysics | Acid |
| California | Alachkar |
| Hurdles | Brain |
| Parkinsons | Calcium |
| Dopa | |
| Dopamine | |
| Molecule | |
| Motor | |
| Movement | |
| Neurotransmitter | |
| Ophthalmic | |
| Parkinsons | |
| Therapeutic | |
| Treatment |
Semantics
| Type | Source | Name |
|---|---|---|
| drug | DRUGBANK | Dopamine |
| drug | DRUGBANK | Calcium |
| disease | MESH | tremors |
| drug | DRUGBANK | Levodopa |
| disease | MESH | dyskinesia |
| disease | MESH | movement disorder |
| pathway | REACTOME | Release |
| drug | DRUGBANK | Etodolac |
| disease | MESH | Neurological Disorders |
| disease | MESH | Stroke |
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