Publication date: Oct 15, 2024

We found that similar to human healthy lungs, MC T s accumulated in the lungs of healthy macaques. Additionally, mast cells (MCs) were increased in the lungs of macaques with PTB (Esaulova et al. , 2021). Chymase positive mast cells are predominant in TB infected human and macaque lung tissue. Lung biopsies from healthy individuals (n = 4) or patients with PTB (n = 5) were stained for tryptase MC T (green) or chymase MC C (red). To identify marker genes for mast cells, we used FindAllMarkers to compare cluster against all other clusters, and FindMarkers to compare selected clusters. (B) Predominance of MC TS in healthy lungs transitioning to MC TCS in early granuloma and becoming MC CS in late granulomas in TB infected lungs. In contrast, chymase rich MCs (MC C s) producing TGF- were detected in proximity to mature granulomas in lung biopsies from PTB (Garcia-Rodriguez et al. , 2021).

Semantics