Exploring the expanding universe of host-virus interactions mediated by viral RNA.

Exploring the expanding universe of host-virus interactions mediated by viral RNA.

Publication date: Oct 03, 2024

RNA is a central molecule in RNA virus biology; however, the interactions that it establishes with the host cell are only starting to be elucidated. In recent years, a methodology revolution has dramatically expanded the scope of host-virus interactions involving the viral RNA (vRNA). A second wave of method development has enabled the precise study of these protein-vRNA interactions in a life cycle stage-dependent manner, as well as providing insights into the interactome of specific vRNA species. This review discusses these technical advances and describes the new regulatory mechanisms that have been identified through their use. Among these, we discuss the importance of vRNA in regulating protein function through a process known as riboregulation. We envision that the elucidation of vRNA interactomes will open new avenues of research, including pathways to the discovery of host factors with therapeutic potential against viruses.

Concepts Keywords
Biology alphavirus
Riboregulation Animals
Stage Host Microbial Interactions
Viral Host-Pathogen Interactions
Years host-virus interactions
Humans
protein-RNA interactions
RNA
RNA interactome
RNA Viruses
RNA-binding protein
RNA, Viral
RNA, Viral
SARS-CoV-2
viral life cycle
viral ribonucleoprotein
virus
Virus Replication

Semantics

Type Source Name
disease IDO host
disease IDO protein
disease IDO process
disease IDO pathogen
pathway KEGG Viral life cycle
disease IDO replication

Original Article

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