Publication date: Sep 30, 2024
Coinfection of pathogenic bacteria and viruses is associated with multiple diseases. During the COVID-19 pandemic, the co-infection of other pathogens with SARS-CoV-2 was one of the important determinants of the severity. Although primarily a respiratory virus gastric manifestation of the SARS-CoV-2 infection was widely reported. This study highlights the possible consequences of SARS-CoV-2 -Helicobacter pylori coinfection in the gastrointestinal cells. We utilized the transfection and infection model for SARS-CoV-2 spike Delta (δ) and H. pylori respectively in colon carcinoma cell line HT-29 to develop the coinfection model to study inflammation, mitochondrial function, and cell death. The results demonstrate increased transcript levels of inflammatory markers like TLR2 (p
| Concepts | Keywords |
|---|---|
| Carcinoma | Co-infection |
| Inflammatory | Gastrointestine |
| Molecular | Helicobacter pylori |
| Viruses | Inflammation |
| Necroptosis | |
| SARS-CoV-2 |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | IDO | role |
| disease | MESH | co-infection |
| disease | IDO | bacteria |
| disease | MESH | COVID-19 pandemic |
| pathway | REACTOME | SARS-CoV-2 Infection |
| disease | MESH | infection |
| disease | MESH | carcinoma |
| disease | IDO | cell |
| disease | MESH | inflammation |
| pathway | KEGG | Necroptosis |