Publication date: Oct 14, 2024
We explored viral and symptom rebound after COVID-19 amubarvimab/romlusevimab monoclonal antibody therapy vs placebo in the randomized ACTIV-2/A5401 trial. Participants underwent nasal SARS-CoV-2 PCR at study days 3, 7, 14, and 28. Viral rebound was defined as RNA ≥3 and ≥0. 5 log10 copies/mL increase from day 3 or 7, and symptom rebound as hospitalization or any moderate/severe symptom for ≥2 days after initial symptom improvement. There was no difference in viral rebound (∼5%/arm) (analysis population n=713) or symptom rebound among participants who initially improved (hazard ratio 0. 95 (95% CI 0. 52, 1. 75, analysis population) n=574);
Concepts | Keywords |
---|---|
A5401 | COVID-19 |
Covid | COVID-19 treatment |
Hospitalization | monoclonal antibodies |
Pcr | non-hospitalized adults |
Viral | SARS-CoV-2 |
symptom rebound | |
viral rebound |
Semantics
Type | Source | Name |
---|---|---|
disease | IDO | symptom |
disease | MESH | COVID-19 |
Original Article
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