Exploring the intersection between orthostatic hypotension and daytime sleepiness in Parkinson’s disease.

Exploring the intersection between orthostatic hypotension and daytime sleepiness in Parkinson’s disease.

Publication date: Jan 15, 2025

Daytime sleepiness, reported in about 50 % of patients with Parkinson’s disease (PD), is associated with high morbidity, poor quality of life and increased risk for accidents. While an association between dysautonomia and daytime sleepiness in early, de-novo PD has been reported, our understanding of the role of medications, cognitive status and co-morbidites on this relationship is inadequate. Data were analyzed from the prospective Cincinnati Cohort Biomarkers Program. The primary outcome of interest was excessive daytime sleepiness (EDS), as measured by the Epworth Sleepiness Scale (ESS; ESS score > 10). The primary exposure variable was orthostatic hypotension (OH). Linear and logistic regression analyses followed by moderated graphical network analyses were conducted to explore the complex association between OH and ESS. Edge weight from graphical network analysis indicates the strength of the association. Data on 453 subjects with PD were analyzed. Median disease duration was 5. 8 years and nearly 90 % were H&Y stage

Concepts Keywords
8years Aged
Biomarkers Cohort Studies
Cincinnati Daytime sleepiness
Parkinson Depression
Sleepiness Dysautonomia
Female
Humans
Hypotension, Orthostatic
Male
Middle Aged
Neurogenic orthostatic hypotension
Orthostatic hypotension
Parkinson Disease
Parkinson’s disease
Prospective Studies

Semantics

Type Source Name
disease MESH orthostatic hypotension
disease MESH daytime sleepiness
disease MESH Parkinson’s disease
disease MESH morbidity
disease MESH dysautonomia
disease MESH Sleepiness
disease MESH Depression
pathway KEGG Parkinson disease

Original Article

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