Publication date: Jan 12, 2025
Background: Resting-state electroencephalography (rs-EEG) has been widely used to explore neural dynamics in Autism Spectrum Condition (ASC). However, inconsistencies in findings across studies remain a challenge, partly due to variations in brain state, such as eye conditions (eyes-open vs. eyes-closed). This study aims to examine rs-EEG differences between ASC and neurotypical (NT) participants, focusing on the influence of eye condition. Methods: A total of 300 participants (126 ASC) were included. Rs-EEG data were analysed across eyes-open, eyes-closed, and difference between eye conditions, with 726 variables assessed per participant. Linear regression and effect size (partial2 ) were used to identify group differences, complemented by cluster-based permutation testing and bootstrapped split-half validation for reliability. Results: Group differences were most pronounced in the eyes-closed condition, particularly for relative power and multiscale entropy (MSE). Compared to neurotypical participants, ASC participants exhibited reduced frontal coarse-scale MSE, increased delta power, and decreased alpha power, suggesting altered local-global neural dynamics. Cross-validation revealed greater reliability of effects in the eyes-closed condition compared to eyes-open or difference between eye conditions. Conclusions: Eye condition plays a critical role in detecting rs-EEG differences between ASC and NT groups, with the eyes-closed condition yielding more consistent and pronounced effects. These findings highlight the importance of controlling brain state in rs-EEG studies and suggest that integrating eye condition effects with other biomarkers may improve identification of neural differences associated with ASC.
Concepts | Keywords |
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Autismdiagnosis | Al |
Baker | Asc |
Sheffieldautismbiomarkers | Autism |
Valuable | Biorxiv |
Closed | |
Condition | |
Differences | |
Doi | |
Eeg | |
Eye | |
Eyes | |
Group | |
Open | |
Participants | |
Preprint |
Semantics
Type | Source | Name |
---|---|---|
disease | MESH | Autism |
drug | DRUGBANK | N-acetylsulfanilyl chloride |
drug | DRUGBANK | Coenzyme M |
drug | DRUGBANK | Platelet Activating Factor |
drug | DRUGBANK | Albendazole |
drug | DRUGBANK | Aspartame |
disease | MESH | clinical relevance |
disease | MESH | ADHD |
drug | DRUGBANK | Diethylstilbestrol |
disease | MESH | autism spectrum disorder |
disease | MESH | neurodevelopmental disorders |
drug | DRUGBANK | Water |
disease | MESH | psychiatric disorders |