Publication date: Jan 15, 2025
The emergence of SARS-CoV-2 increased interest in cellular immunity established by infections with human coronaviruses (HCoVs). Using PBMC from a cohort of human subjects collected prior to 2019, we assessed the abundance and phenotype of these CD4 T cells using cytokine Elispot assays. Unexpectedly, cytotoxic potential was uniquely enriched amongst HKU1-reactive CD4 T cells, as measured by quantification of granzyme producing cells. Also, although dramatic losses in HCoV-specific CD4 T cells abundance for OC43, NL63 and 229E-specific cells were observed in older subjects relative to younger adults, HKU1-reactive cells exhibited minimal age-dependent differences in this phenotype.
Concepts | Keywords |
---|---|
Cd4 | aging |
Coronaviruses | CD4 T cells |
Genes | Coronavirus |
Older | cytotoxic cells |
Elispots | |
human | |
immunity |
Semantics
Type | Source | Name |
---|---|---|
disease | MESH | infections |
Original Article
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