Association between triglyceride/high density lipoprotein ratio and incidence risk of Parkinson’s disease: a population-based cohort study.

Association between triglyceride/high density lipoprotein ratio and incidence risk of Parkinson’s disease: a population-based cohort study.

Publication date: Jan 16, 2025

The association between insulin resistance and increased risk of Parkinson’s disease (PD) has rarely been investigated. Our study aimed to investigate the association between the triglyceride/high-density lipoprotein (TG/HDL) ratio (which represents insulin resistance), and the incidence risk of PD in the general population. This study was conducted using data from the National Health Insurance Service-Health Screening Cohort Database of South Korea (2002-2019). We enrolled 310,023 participants who had no previous PD history and who had undergone more than three repeated measurements for the TG/HDL cholesterol ratio. The diagnosis of PD was determined using the International Classification of Diseases, 10th Revision code G20, specific reimbursement codes for Rare Intractable Diseases of V124, and a history of anti-PD drug prescription. During a median of 9. 64 years (interquartile range 8. 72-10. 53), 4,587 individuals (1. 47%) had an incidence of PD. Considering the multivariable time-dependent Cox proportional hazard model with repeated measures of average TG/HDL cholesterol ratio, a per unit increase in TG/HDL cholesterol ratio significantly increased the risk of PD in the entire cohort (hazard ratio (HR), 1. 010; 95% confidence interval (CI), 1. 001-1. 020). These repeated measures of the average TG/HDL cholesterol ratio were associated with the incidence risk of PD in a J-shaped pattern for the entire diabetes mellitus (DM) and non-DM cohorts in restricted cubic spline analysis. Compared to the lowest tertiles (T1), the highest tertiles (T3) were positively associated with the incidence risk of PD (HR: 1. 149, 95% CI 1. 065-1. 239 in the entire cohort, p for trend 

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Concepts Keywords
Cholesterol Adult
Diabetes Aged
Korea Cholesterol, HDL
Parkinson Cholesterol, HDL
V124 Cohort Studies
Diabetes mellitus
Female
Humans
Incidence
Insulin Resistance
Insulin resistance
Lipoproteins, HDL
Lipoproteins, HDL
Male
Middle Aged
Parkinson Disease
Parkinson’s disease
Proportional Hazards Models
Republic of Korea
Risk Factors
Triglycerides
Triglycerides

Semantics

Type Source Name
disease MESH Parkinson’s disease
disease MESH insulin resistance
pathway KEGG Insulin resistance
disease MESH diabetes mellitus
disease MESH tremor
drug DRUGBANK Coenzyme M
drug DRUGBANK Dopamine
disease MESH lifestyle factors
drug DRUGBANK Ethanol
disease MESH death
disease MESH causality
drug DRUGBANK Dextrose unspecified form
disease MESH Hypertension
disease MESH dyslipidemia
disease MESH comorbidity
drug DRUGBANK Amantadine
drug DRUGBANK Carbidopa
drug DRUGBANK Levodopa
drug DRUGBANK Selegiline
drug DRUGBANK Rasagiline
disease MESH secondary Parkinsonism
disease MESH Parkinsonism
disease MESH liver disease
drug DRUGBANK Cholesterol
disease MESH metabolic syndrome
disease MESH cerebrovascular disease
disease MESH coronary artery disease
disease MESH dementia
disease MESH neuroinflammation
pathway REACTOME Autophagy
disease MESH mitochondrial dysfunction
drug DRUGBANK Pioglitazone
disease MESH atrial fibrillation
disease MESH stroke
disease MESH clinical significance
drug DRUGBANK L-Citrulline
pathway KEGG Parkinson disease
disease MESH Huntington’s disease
disease MESH COVID 19
disease MESH Cardiovascular Risk
disease MESH cardiovascular disease
drug DRUGBANK Tolbutamide
disease MESH arterial stiffness
disease MESH Tooth Loss
disease MESH gastrointestinal cancer
disease MESH complications
drug DRUGBANK Metformin
disease MESH Obesity
drug DRUGBANK Guanosine
drug DRUGBANK Sitagliptin
drug DRUGBANK Liraglutide
drug DRUGBANK Rotenone
disease MESH Atherosclerosis
disease MESH ST segment elevation myocardial infarction
pathway REACTOME Reproduction

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