HIV clinical outcomes among people with HIV and diabetes mellitus in Kampala, Uganda; A matched retrospective cohort study.

HIV clinical outcomes among people with HIV and diabetes mellitus in Kampala, Uganda; A matched retrospective cohort study.

Publication date: Jan 17, 2025

Suppressive antiretroviral treatment (ART) has resulted into prolonged survival of people with HIV (PWH) in Sub-Saharan Africa (SSA) with resultant increase in the incidence of non-communicable diseases (NCD), such as diabetes mellitus (DM). However, there is a lack of data on the effect of DM on HIV-related outcomes among PWH in this setting. The study aimed to compare HIV clinical outcomes (viral load suppression, retention in care, hospitalization, tuberculosis, and mortality) between PWH with DM and those without at two large HIV clinics in Kampala, Uganda. We conducted a matched retrospective cohort study using secondary data of PWH with DM and PWH without DM from January 2020 to June 2022. We used descriptive statistics to compare baseline characteristics and a chi-square test to compare the outcomes between the HIV/DM and HIV/no DM groups. The cohort consisted of 243 PWH diagnosed with DM matched with 1221 PWH without DM. We analysed 1,469 participant records: 1,009 (68. 7%) from Mulago ISS clinic and 460 (31. 3%) from Kisenyi HC IV. Most study participants (63. 6%) were female, and the mean age was 43 years (standard deviation [SD] 11) and 38 years (SD 10) for those with DM and without DM, respectively. PWH with DM had significantly higher odds of hospitalization (adjusted odds ratio [AOR] 4. 94; 95% CI: 1. 93-12. 66; p = 0. 001) and were less likely to be retained in care (AOR 0. 12, 95% CI: 0. 07-0. 20 p =

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Concepts Keywords
Clinics Care
Diabetes Clinical
Hiv Cohort
June Compare
Diabetes
Dm
Hiv
Hospitalization
Kampala
Matched
Mellitus
Outcomes
Pwh
Retrospective
Uganda

Semantics

Type Source Name
disease MESH diabetes mellitus
disease MESH non-communicable diseases
disease MESH viral load
disease MESH tuberculosis
pathway KEGG Tuberculosis
disease MESH AIDS
disease MESH Infectious Diseases

Original Article

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