Prevalence of Pulmonary Embolism in COVID-19 Positive Critically Ill Children.

Prevalence of Pulmonary Embolism in COVID-19 Positive Critically Ill Children.

Publication date: Jan 01, 2025

To investigate the prevalence of pulmonary embolism (PE) in children admitted to critical care diagnosed with COVID-19 infection. Retrospective database study. Data reported to the Virtual Pediatric Systems, 2018-2021. Patients 28 days to younger than 18 years old, admitted to a PICU with either PE or COVID-19 diagnoses. None. Among the PE-positive subgroups, from January 2020 to December 2021, 78 patients (14%) had an acute COVID-19 infection. The prevalence of PE pre-pandemic period (2018-2019) was 0. 19% and for pandemic period (2020-2021) was 0. 26% (p < 0. 001). During the pandemic period, the prevalence of PE for COVID-negative patients was 0. 21% and for COVID-positive patients was 1. 01% (p < 0. 001). The result shows that the chance to develop PE for COVID-positive patients is 4. 8 times that for COVID-negative patients during the pandemic. In the subgroup of the PE-positive patients, 55. 1% were Black or African American in the COVID-positive group and 19% in the COVID-negative group (p < 0. 001). A multivariable logistic regression showed that race was an independent risk factor for COVID in PE-positive patients. Our study demonstrates a significant increase in the prevalence of PE among pediatric patients admitted to PICUs during the COVID-19 pandemic compared with pre-pandemic. Our study indicates that COVID-positive patients are 4. 8 times more likely to develop PE than COVID-negative patients. Additionally, the study highlights substantial racial disparities in the prevalence of PE, with Black or African American patients being disproportionately affected.

Concepts Keywords
American Adolescent
December Child
Pandemic Child, Preschool
Pediatric COVID-19
Critical Illness
Female
Humans
Infant
Infant, Newborn
Male
Prevalence
Pulmonary Embolism
Retrospective Studies
Risk Factors
SARS-CoV-2
White

Semantics

Type Source Name
disease MESH Pulmonary Embolism
disease MESH COVID-19
disease MESH Critically Ill
disease MESH infection

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