An interrupted time series study of the leprosy case detection in Brazil after the COVID-19 pandemic.

Publication date: Mar 21, 2025

COVID-19 pandemics affected several health systems processes, including leprosy care. This study aimed to estimate the impact of the COVID-19 pandemic on the leprosy case detection rate in Brazil from 2017 to 2022. Data was retrieved from Sinan, a Brazilian notification system, and monthly leprosy detection rate in the overall population and in individuals under 15 years of age were the main outcomes. The series was interrupted in February 2020, when the COVID-19 public health emergency was declared in Brazil. The data were analysed via Prais-Winsten regression. Over the 72 months analysed, the COVID-19 pandemic led to an immediate 0. 55 reduction (95% CI 0. 48-0. 62) in the overall leprosy detection rate, with a subsequent monthly increase of 1. 01 (95% CI 1. 00-1. 02). For the population under 15 years of age, the pandemic caused an immediate 0. 48 reduction (95% CI 0. 40-0. 57), followed by a monthly increase of 1. 01 (95% CI 1. 01-1. 02) after the onset of the pandemic. Subnational analysis revealed that most federative units followed the trend for the overall detection rate, but high heterogeneity was observed regarding individuals under 15 years of age. Therefore, it is urgent to target strategies to minimize delayed diagnosis and long-term consequences of leprosy.

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Concepts Keywords
15years Adolescent
72months Adult
Brazil Brazil
Covid COVID-19
Pandemic COVID-19
Epidemiology
Female
Hansen’s disease
Humans
Leprosy
Leprosy
Male
Pandemics
SARS-CoV-2

Semantics

Type Source Name
disease MESH leprosy
disease MESH COVID-19 pandemic
disease MESH emergency
drug DRUGBANK Ribostamycin
drug DRUGBANK Coenzyme M
disease MESH morbidity
disease MESH endemic disease
disease MESH aids
disease IDO country
disease MESH neglected disease
disease IDO intervention
disease MESH social vulnerability
disease MESH hepatitis
disease MESH chronic diseases
drug DRUGBANK Proline
disease MESH complications
disease MESH coinfection
disease MESH suicides
disease MESH tuberculosis
pathway KEGG Tuberculosis
disease MESH visceral leishmaniasis
disease MESH Schistosomiasis
disease MESH Noncommunicable diseases
disease MESH lifestyles
pathway REACTOME Reproduction

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