Publication date: Mar 21, 2025

Interoception, the representation of internal body states, plays an important role in mental health. While functional neuroimaging links Major Depressive Disorder (MDD) relapse vulnerability to stress-induced inhibition of sensorimotor regions, its association with structural changes in interoceptive networks remains unclear. A secondary analysis explored relationships between gray matter volume and relapse vulnerability in remitted MDD patients (N = 85), with two data acquisitions surrounding eight-weeks of prophylactic psychotherapy followed by a two-year follow-up. Participants were randomly assigned to either Cognitive Behavioral Therapy or Mindfulness-Based Cognitive Therapy (MBCT). Mixed-effects models were applied to study the relationships between cortical thickness, time, and intervention type with clinical variables such as relapse status, residual symptoms, and decentering, adjusting for relevant covariates. Analyses were conducted at whole brain levels as well as in pre-defined regions of interest, focusing on sensory regions implicated by prior research. Relapse was consistently linked to greater cortical thickness in the left superior circular sulcus of the insula and the left anterior occipital sulcus. Residual symptoms correlated with increased cortical thickness in the left insula and right precentral regions, while decentering was linked to reduced thickness in the middle temporal and inferior parietal regions. MBCT participants showed greater cortical thickness increases in the right superior temporal gyrus over time. MDD vulnerability was unexpectedly linked to greater cortical thickness in sensory and prefrontal brain regions, suggesting that depression vulnerability may reflect maladaptive skill acquisition. MBCT may promote gray matter growth in the right superior temporal region. ClinicalTrials. govNCT01178424.

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