Long-term effects of SARS-CoV-2 infection on metal homeostasis.

Publication date: Apr 01, 2025

The outbreak of COVID-19 pandemic has caused substantial health loss worldwide, and the long-term sequelae of COVID, resulting from repeated coronavirus infection, have emerged as a new public health concern. We report the widespread presence of abnormal metallomic profiles in the sera of patients who have recovered from SARS-CoV-2 coronavirus infection, even after 6 months post-discharge from hospital. We measured the concentrations of Fe, Cu, Zn, Se, Cr, Mn, Ba, Ni, Pb, Ag, As, Cd, Co, and V in the sera of 25 recovered participants and 38 healthy controls in the cross-sectional study. Higher concentrations of Cu, Ag, As, Ba, Cd, Ni, Pb, Cr and V were observed in the recovered participants, whereas lower concentrations of Fe and Se were obtained in these participants. Except for Zn, Mn, and Co, all other elements showed significant differences (p 

Concepts Keywords
Coronavirus Adult
Hospital Aged
Metallomic Coronavirus
Months COVID-19
Pandemic COVID-19
Cross-Sectional Studies
Female
Homeostasis
Humans
Male
Metabolism
Metal
Metallome
Metals
Metals
Middle Aged
SARS-CoV-2

Semantics

Type Source Name
disease MESH SARS-CoV-2 infection
pathway REACTOME SARS-CoV-2 Infection
disease MESH sequelae
disease MESH coronavirus infection
pathway REACTOME Metabolism

Original Article

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