Publication date: Apr 01, 2025

Major depressive disorder (MDD) is a stress-related disease that affects women more often than men. Music therapy (MT) has been shown to be effective in the treatment of MDD. However, clinical trials investigating the effects of MT on psychological and psychobiological stress-related outcomes in women suffering from MDD are still scarce. This study was conducted as a randomised controlled trial, with participants assigned to either an intervention group (IG), which received group MT (GMT), or a waitlist control group (CG), which received GMT 6 months later. The primary objective was to assess the impact of GMT on psychological stress outcomes (chronic stress, stress coping, and stress experienced in daily life) and psychobiological stress markers (diurnal salivary cortisol levels and circadian heart rate variability), considering the effects of both group allocation and time. Outcome measurements were taken before, immediately after, and-for some variables-10 weeks following the intervention period. A total of 102 women 18-65 years old and diagnosed with current MDD took part in the study. Overall, the IG demonstrated significantly stronger stress-reducing effects than the CG. Significant improvements were observed in general stress coping, positive thinking, daily life stress, and cortisol levels. GMT is a cost-effective and non-invasive approach to effectively address the stress-related psychological and psychobiological burden associated with MDD. To demonstrate long-term effects and gain a better understanding of the underlying mechanisms, further methodologically robust studies are needed. TRAIL REGISTRATION: The MUSED study was pre-registered at the German Clinical Trials Registry (DRKS00016616). All study-related procedures were published in detail in a study protocol.

Semantics

Original Article