Publication date: Mar 21, 2025

The aim of this study was to evaluate the association between SARS-CoV-2 vaccination and the occurrence of thrombotic complications in patients admitted to intensive care for severe COVID-19 pneumonia. Observational, descriptive, prospective, multicentre study. Intensive care units of five university hospitals. A total of 255 patients admitted to the intensive care unit (ICU) with SARS-CoV-2 pneumonia, confirmed by RT-PCR in throat swab or tracheal aspirate, starting the date the first vaccinated patient against SARS-CoV-2 was admitted in one of the participating ICUs, were included in the analysis. Vaccination status against SARS-CoV-2 and thrombotic events. 18. 8% of patients had received some form of vaccination. Thrombotic events occurred in 21. 2% of patients. Lack of vaccination was associated with thrombotic events (OR 5. 024; 95% CI: 1. 104-23. 123; p = 0. 0037) and death (OR 5. 161; 95% CI: 1. 075-24. 787; p = 0. 04). ICU mortality was not associated with the occurrence of thrombotic complications. In this series of patients, vaccination against SARS-CoV-2 reduced the risk of thrombotic events and mortality in patients with severe COVID-19 admitted to the ICU. Thrombotic complications did not alter ICU mortality.

Semantics