Publication date: Mar 25, 2025
Understanding this connection required extensive exploration, and this process alone took over a year. Neuroscience research can feel like searching for a needle in a haystack. Eventually, the research became more structured and progressed more smoothly. Sixth Tone: What was your daily life like over the past five years?Wu: It was incredibly demanding. There are still many unresolved questions, particularly regarding the physiological function of FAM171A2, its structure, and whether it can truly serve as a viable drug target. A major obstacle has been the lack of a clearly identified therapeutic target. Previous studies have identified potential targets, but they were mainly found in non-nerve cells, such as microglia. One of our current challenges is that the new drug candidates weve identified have certain limitations. Not all research yields promising results. A year into what was supposed to be a short-term study of a gene linked to Parkinsons disease, Wu Kaimin was ready to give up.
| Concepts | Keywords |
|---|---|
| China | Alpha |
| Gatekeeper | Diseases |
| Neuroscience | Drug |
| Pathogenic | Identified |
| Parkinsons | |
| Pathological | |
| Potential | |
| Research | |
| Sixth | |
| Synuclein | |
| Target | |
| Tone | |
| Wu | |
| Year | |
| Years |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | muscle rigidity |
| disease | MESH | tremors |
| disease | MESH | neurodegenerative disorder |
| pathway | REACTOME | Neurodegenerative Diseases |
| disease | MESH | disease progression |
| disease | MESH | frontotemporal dementia |
| disease | MESH | uncertainty |