Publication date: Mar 24, 2025
BackgroundThe motor reserve estimates (MRes) derived from a residual approach correlate with motor severity in Parkinson’s disease (PD), leaving the independent effect of motor reserve on clinical outcomes unclear. ObjectiveInvestigate the independent influence of motor reserve on the long-term outcome. MethodsUsing the Parkinson’s Progression Markers Initiative (PPMI) and Pusan National University Hospital (PNUH) datasets, we investigated the association of MRes with progression of motor severity as well as risk of phenoconversion to Hoehn & Yahr (H&Y) stage 3. Two MRes types were calculated: (1) original MRes, negative conversion of standardized residuals from a generalized linear model (GLM) between putaminal dopamine transporter (DAT) levels and motor severity, and (2) modified MRes, standardized residuals from the GLM between original MRes and motor scores. ResultsOriginal MRes correlated with baseline motor scores, while modified MRes did not. Modified MRes in both cohorts were associated with a rapid increase in motor severity (linear mixed effect model, interaction between MRes and disease duration; PPMI, Movement Disorder Society sponsored Unified Parkinson Disease Rating Scale part III [MDS-UPDRS III], estimate 2. 248 cD7 10, p
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| Concepts | Keywords |
|---|---|
| Dopamine | motor progression |
| Hospital | motor reserve |
| Objectiveinvestigate | Parkinson’s disease |
| Parkinsons | |
| Resultsoriginal |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Parkinson disease |
| pathway | KEGG | Parkinson disease |
| disease | MESH | Movement Disorder |