Publication date: Mar 25, 2025
People with major depressive disorder (MDD) enter rapid-eye movement (REM) sleep sooner and remain in that sleep stage longer than those with insomnia. Insomnia often occurs before MDD onset and research has suggested a correlation between this onset with both emotional dysregulation and emotional processing. Of the 103 studies included, 17 focused on MDD and 86 focused on insomnia. While prior research has suggested the 2 conditions have a bidirectional relationship, the dynamics and mechanisms underlying the association are not completely understood.
| Concepts | Keywords |
|---|---|
| Depressive | Ci |
| Increased | Compared |
| January | Control |
| Polysomnography | Disorder |
| Sleep | Emotional |
| Group | |
| Healthy | |
| Insomnia | |
| Mdd | |
| Model=0 | |
| Onset | |
| Psg | |
| Rem | |
| Sleep | |
| Stage |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Insomnia |
| disease | MESH | major depressive disorder |
| disease | MESH | mental disorders |
| disease | MESH | sleep fragmentation |
| drug | DRUGBANK | Tropicamide |
| disease | MESH | affective disorder |
Original Article
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