Publication date: Apr 01, 2025
To investigate the epidemiology of latent tuberculosis infection (LTBI) and associated risk factors among adults in Al-Madinah, KSA, and to identify vulnerable populations for targeted interventions. This hospital-based cross-sectional study was conducted at Prince Mohammed Bin Abdulaziz Hospital, Al-Madinah, from January 2021 to December 2022. Participants aged >14 years were screened for LTBI using the QuantiFERON(R)-TB Gold In-Tube test. People with active tuberculosis were excluded. Data on demographics, comorbidities, and risk factors were analyzed using multivariate logistic regression to identify factors associated with LTBI. In total, 773 participants were included and 291 (37. 6 %) tested positive for LTBI. Multivariate analysis identified greater age, male sex, diabetes mellitus, and connective tissue disorders as significant risk factors for LTBI. Non-Saudi nationality was associated with higher odds of LTBI (adjusted odds ratio [aOR], 3. 86; 95 % confidence interval (95 % CI), 1. 80-8. 27), whereas the risk was lower for Saudi nationals (aOR, 0. 34; 95 % CI, 0. 25-0. 47). This study highlights the burden of LTBI in Al-Madinah, and specific demographic and medical risk factors. These findings underscore the importance of personalized public health strategies and preventive measures for controlling LTBI progression in high-risk populations.
Concepts | Keywords |
---|---|
December | Interferon-gamma release assay |
Diabetes | Latent tuberculosis infection |
Hospital | |
Nationals | |
Saudi |
Semantics
Type | Source | Name |
---|---|---|
disease | MESH | latent tuberculosis |
drug | DRUGBANK | Gold |
disease | MESH | tuberculosis |
pathway | KEGG | Tuberculosis |
disease | MESH | diabetes mellitus |
pathway | REACTOME | Release |
disease | IDO | assay |