Publication date: Mar 26, 2025
Researchers know that in the brain, the neurotransmitter dopamine accelerates -synuclein aggregation, especially when it is oxidized into dopamine quinone. The nitrite oxidizes iron, which in turn can oxidize dopamine, forming dopamine quinone. Biol 2024, DOI: 10. 1021/acschembio. 4c00095). When oxygen is unavailable, some gut bacteria can use nitrate as an alternative electron acceptor for cellular respiration, generating nitrite.
| Concepts | Keywords |
|---|---|
| California | Aggregation |
| Microbiome | Bess |
| Parkinsons | Brain |
| Dopamine | |
| Gut | |
| Metabolism | |
| Microbial | |
| Microbiome | |
| Neurons | |
| Nitrite | |
| Parkinson | |
| Quinone | |
| Signaling | |
| Synuclein | |
| Years |
Semantics
| Type | Source | Name |
|---|---|---|
| pathway | REACTOME | Metabolism |
| disease | MESH | Parkinson’s disease |
| disease | MESH | tremors |
| drug | DRUGBANK | Dopamine |
| disease | MESH | causes |
| disease | MESH | death |
| disease | MESH | cause of death |
| drug | DRUGBANK | Oxygen |
| drug | DRUGBANK | Nitrate |
| drug | DRUGBANK | Nitrite |
| drug | DRUGBANK | Iron |
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