Publication date: Mar 25, 2025
The aim of the present study was to quantify the rate of thromboembolic events (TE) in pregnant women with SARS-CoV-2 infection and to characterize risk factors to provide a basis for individualized recommendation on prophylactic measures. CRONOS is a multicenter, prospective observational study conducted in Germany and Austria during the COVID-19 pandemic. Pregnant women with confirmed SARS-CoV-2 infection were enrolled. Data on demographics, medical history, COVID-19-related aspects, and pregnancy and birth outcomes were collected. TE was particularly queried and used as the primary outcome. A combination of “TE,” “maternal or fetal death,” or “severe postpartum hemorrhage” was defined as a secondary endpoint. Risk analyses were performed using univariate and multivariable logistic regression models. Data from 8033 pregnant patients showed 40 TEs (0. 5% incidence). TE rates were 10% in ICU patients, 0. 2-0. 4% in those with moderate-to-mild COVID-19, and
Open Access PDF
| Concepts | Keywords |
|---|---|
| Austria | Blood transfusion |
| Germany | Heparin |
| Pandemic | Invasive ventilation |
| Postpartum | Maternal death |
| Pregnancy | Stillbirth |