Publication date: Mar 26, 2025
By assessing the standard-of-care regimen for tuberculosis (TB) in BALB/c and C3HeB/FeJ mice, we demonstrate that rifampin, with or without pyrazinamide, is essential for an effective bactericidal response and suppression of resistance. Potency measurements in an in vitro lipid-rich model and a rabbit caseum assay recapitulate the significance of rifampin as a sterilizing agent. These outcomes align with clinical performance, thus emphasizing the value of in vitro predictive tools and murine TB models with human-like pathology.
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| Concepts | Keywords |
|---|---|
| Bactericidal | C3HeB/FeJ |
| Clinical | caseum |
| Mice | relapse |
| Rich | rifafour |
| Tuberculosis | tuberculosis |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | IDO | bactericidal |
| disease | MESH | tuberculosis |
| pathway | KEGG | Tuberculosis |
| drug | DRUGBANK | Rifampicin |
| drug | DRUGBANK | Pyrazinamide |
| disease | IDO | assay |
| disease | MESH | relapse |
| drug | DRUGBANK | Isoniazid |
| drug | DRUGBANK | Ethambutol |
| disease | IDO | bacteriostatic |
| disease | MESH | granulomas |
| disease | IDO | susceptibility |
| drug | DRUGBANK | Butyric Acid |
| disease | IDO | bacteria |
| drug | DRUGBANK | Ilex paraguariensis leaf |
| disease | MESH | infection |
| drug | DRUGBANK | Activated charcoal |
| disease | MESH | drug interactions |
| pathway | REACTOME | Translation |
| drug | DRUGBANK | Etoperidone |
| drug | DRUGBANK | Dimethyl sulfoxide |
| disease | MESH | Allergy |
| disease | MESH | Infectious Diseases |
| drug | DRUGBANK | Moxifloxacin |
| drug | DRUGBANK | Bedaquiline |
| disease | MESH | drug tolerance |
| disease | MESH | pulmonary tuberculosis |
| drug | DRUGBANK | Carboxyamidotriazole |
Original Article
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