Publication date: Apr 15, 2025
Results of this cohort study suggest that genetic predisposition related to neuroticism, cognitive function, and sleep patterns had a significant association with the development of TRD. In the current study, researchers examined associations between genetic factors and TRD and assessed the genetic role in TRD etiology. However, no significant relationship has been identified, despite a noted higher heritability than treatment-responsive major depressive disorder (trMDD). Increased TRD risk was associated with predisposition for insomnia (odds ratio [OR], 1. 11; 95% CI, 1. 07-1. 15) and with specific neuroticism (OR, 1. 11; 95% CI, 1. 07-1. 16). Possible association between PGS and TRD compared with trMDD was determined with logistic regressions. Association between progressions from MDD to TRD with PGS were determined with a Cox proportional hazard model. Please see the original reference for a full list of authors disclosures.
| Concepts | Keywords |
|---|---|
| Biotech | Ci |
| Genotyping | Cognitive |
| Hispanic | Depression |
| Psychiatry | Education |
| Function | |
| Genetic | |
| Neuroticism | |
| Participants | |
| Pgs | |
| Predisposition | |
| Related | |
| Sleep | |
| Traits | |
| Trd | |
| Treatment |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Neuroticism |
| disease | MESH | Depression |
| disease | MESH | schizophrenia |
| disease | MESH | major depressive disorder |
| disease | MESH | etiology |
| disease | MESH | insomnia |