Publication date: Apr 15, 2025
In fact, this group used statistics to define the rate at which CAGs expand in these vulnerable mouse brain cells: its about 8. 8 CAG repeats per month. In this type of HD mouse, CAG repeats get longer over time, especially within the cells of the striatum. Somatic instability is the concept that CAG repeats expand over time in some types of cells, particularly cells that are vulnerable in HD. Lots of genes are producing more or less RNA than they are meant to, especially within medium spiny neurons, the cells that are most vulnerable in HD. The buildup of these clumps is a classic feature of HD that many scientists suspect could be toxic to brain cells. Publications like this one represent years of collaborative work among a large team, shaped by frequent input from an international community of HD scientists. (These rates of expansion do NOT apply to humans – these mice start out with 140 repeats and are designed for experimentation.
| Concepts | Keywords |
|---|---|
| Astrocytes | Brain |
| California | Cag |
| Flurry | Cags |
| Mice | Cells |
| Transcriptomics | Expansion |
| Hd | |
| Huntingtin | |
| Instability | |
| Lab | |
| Msh3 | |
| Pms1 | |
| Repair | |
| Repeat | |
| Repeats | |
| Yang |
Semantics
| Type | Source | Name |
|---|---|---|
| pathway | REACTOME | DNA Repair |
| disease | MESH | gait |