Publication date: Apr 13, 2025
Neuroimaging allows the study of brain structures that previously were undetectable due to their small size and location. Here-in we focused on the core catecholaminergic circuitries in the human brain, involving the coerulean noradrenergic (or norepi-nephrine, NE) and dopaminergic (DA) systems. Using T1-weighted MRI morphometry and dMRI tractography, this study was carried out in one post-mortem human ultra-high-resolution dataset of the brainstem and diencephalon and in healthy human datasets from the Human Connectome Project repository. We investigated 26 connections of brainstem origin (13 in the left side and 13 in the right side) associated with the NE and DA circuitries. We delineated the coerulean NE and DA core central cate-cholaminergic circuitries of the brainstem and hypothalamus in the post-mortem dataset, including all targeted fiber connec-tions. Importantly, this was also achieved in the HCP datasets. These results emphasize the importance of multispectral neu-roimaging in the study of chemical neuroanatomical circuitries and its application in clinical conditions such as cardiovascular disease, major depression, schizophrenia, and other disorders associated with chronic stress and brain-immune interactions such as COVID-19.
| Concepts | Keywords |
|---|---|
| April | Biorxiv |
| Cats | Brain |
| Freesurfer | Brainstem |
| Harvard | Circuitry |
| Neuropsychiatric | Coerulean |
| Connections | |
| Figure | |
| Group | |
| Hcp | |
| Nucleus | |
| Origin | |
| Preprint | |
| Subjects | |
| System | |
| Vta |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | cardiovascular disease |
| disease | MESH | COVID-19 |
| disease | MESH | depression |
| disease | MESH | schizophrenia |
| drug | DRUGBANK | Norepinephrine |
| drug | DRUGBANK | Dopamine |
| disease | MESH | long COVID |
| drug | DRUGBANK | Epinephrine |
| drug | DRUGBANK | L-Tyrosine |
| disease | MESH | clinical relevance |
| drug | DRUGBANK | Coenzyme M |
| drug | DRUGBANK | Gold |
| disease | MESH | PUs |
| drug | DRUGBANK | Heparin |
| drug | DRUGBANK | Formaldehyde |
| drug | DRUGBANK | Phosphate ion |
| drug | DRUGBANK | Gadoteridol |
| drug | DRUGBANK | Flunarizine |
| drug | DRUGBANK | Pentaerythritol tetranitrate |
| drug | DRUGBANK | Dimercaprol |
| drug | DRUGBANK | Acetylcysteine |
| drug | DRUGBANK | Isoxaflutole |
| disease | MESH | Parkinson’s disease |
| disease | MESH | movement disorder |
| disease | MESH | restless legs syndrome |
| disease | MESH | ADHD |
| disease | MESH | drug addiction |
| disease | MESH | syndrome |
| disease | MESH | abnormalities |
| disease | MESH | apathy |