Publication date: May 20, 2025
Among them, NMDA receptors determine the intensity and duration of information transmission. When these regulators fail, signals can flow excessively, resulting in overactive brain function. “Professor Ko commented, “The MDGA2 protein is highly associated with various brain developmental diseases, such as autism spectrum disorders. “More information: Hyeonho Kim et al, EphB2 receptor tyrosine kinase-mediated excitatory synaptic functions are negatively modulated by MDGA2, Progress in Neurobiology (2025). Conversely, signals can weaken, hindering normal brain function. Surrounding proteins, including EphB2, are also highly relevant, so we will expand our research to preclinical studies. Editors have highlighted the following attributes while ensuring the content’s credibility:Analysis of MDGA2-EphB2 interaction using cell-surfacebinding assays. Diagrams depicting the deletion variants of EphB2 (A) or MDGA2 (C) used in our molecular replacement experiments.
Concepts | Keywords |
---|---|
Autism | Autism |
Glycosylphosphatidylinositol | Brain |
Professors | Ephb2 |
Excitatory | |
Function | |
Key | |
Mdga2 | |
Nmda | |
Proteins | |
Receptor | |
Receptors | |
Signals | |
Synapse | |
Synapses | |
Team |
Semantics
Type | Source | Name |
---|---|---|
drug | DRUGBANK | Ketamine |
disease | MESH | autism |
disease | MESH | brain diseases |
disease | MESH | autism spectrum disorders |