Proteins regulating NMDA receptor function offer hope for targeted autism therapies

Proteins regulating NMDA receptor function offer hope for targeted autism therapies

Publication date: May 20, 2025

Among them, NMDA receptors determine the intensity and duration of information transmission. When these regulators fail, signals can flow excessively, resulting in overactive brain function. “Professor Ko commented, “The MDGA2 protein is highly associated with various brain developmental diseases, such as autism spectrum disorders. “More information: Hyeonho Kim et al, EphB2 receptor tyrosine kinase-mediated excitatory synaptic functions are negatively modulated by MDGA2, Progress in Neurobiology (2025). Conversely, signals can weaken, hindering normal brain function. Surrounding proteins, including EphB2, are also highly relevant, so we will expand our research to preclinical studies. Editors have highlighted the following attributes while ensuring the content’s credibility:Analysis of MDGA2-EphB2 interaction using cell-surfacebinding assays. Diagrams depicting the deletion variants of EphB2 (A) or MDGA2 (C) used in our molecular replacement experiments.

Concepts Keywords
Autism Autism
Glycosylphosphatidylinositol Brain
Professors Ephb2
Excitatory
Function
Key
Mdga2
Nmda
Proteins
Receptor
Receptors
Signals
Synapse
Synapses
Team

Semantics

Type Source Name
drug DRUGBANK Ketamine
disease MESH autism
disease MESH brain diseases
disease MESH autism spectrum disorders

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