Publication date: May 20, 2025
The delivery systems have been tested, or validated, in intact living systems, which is an important step for introducing new tools for widespread use. The new collection of gene delivery resources lays the groundwork for more precise treatments that target only affected cells in the brain, spinal cord, or brain blood vessels. The Armamentarium for Precision Brain Cell Access aims to develop precise and reproducible access to cells and circuits in experimental research models of the brain and spinal cord. The new delivery systems carry genetic material into the brain and spinal cord for targeted use by specific cell types. -With these delivery systems, we can now access and manipulate specific cells in the brain and spinal cord – access that was not possible before at this scale. ” These delivery systems are a significant step toward future precise gene therapy to the brain that could safely control errant brain activity with high precision. Summary: Scientists have engineered dozens of adeno-associated virus (AAV) systems that ferry genes to specific neuron and glial subtypes in the brain and spinal cord with unprecedented accuracy.
| Concepts | Keywords |
|---|---|
| Alzheimers | Aav |
| Neuroscience | Brain |
| Newsauthor | Cord |
| S10mh126994 | Delivery |
| Truck | Enhancer |
| Genetic | |
| Manipulate | |
| Neuroscience | |
| Specific | |
| Spinal | |
| Subtypes | |
| Switches | |
| Systems | |
| Target | |
| Vectors |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | causes |
| disease | MESH | Parkinson’s disease |
| disease | MESH | epilepsy |
| disease | MESH | death |
| disease | MESH | Huntington’s disease |
| disease | MESH | Alzheimer’s disease |
| drug | DRUGBANK | Tropicamide |
| disease | MESH | brain disorders |
| disease | MESH | amyotrophic lateral sclerosis |
| pathway | KEGG | Amyotrophic lateral sclerosis |
| disease | MESH | spinal muscular atrophy |