The highs and lows of monoamine oxidase as molecular target in cancer: an updated review.

ingentiumby ingentium

In Parkinson's Disease Literature.

Publication date: Jun 01, 2025

The global burden of cancer as a major cause of death and invalidity has been constantly increasing in the past decades. Monoamine oxidases (MAO) with two isoforms, MAO-A and MAO-B, are mammalian mitochondrial enzymes responsible for the oxidative deamination of neurotransmitters and amines in the central nervous system and peripheral tissues with the constant generation of hydrogen peroxide as the main deleterious ancillary product. However, given the complexity of cancer biology, MAO involvement in tumorigenesis is multifaceted with different tumors displaying either an increased or decreased MAO profile. MAO inhibitors are currently approved for the treatment of neurodegenerative diseases (mainly, Parkinson’s disease) and as secondary/adjunctive therapeutic options for the treatment of major depression. Herein, we review the literature characterizing MAO’s involvement and the putative role of MAO inhibitors in several malignancies, and also provide perspectives regarding the potential biomarker role that MAO could play in the future in oncology.

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Concepts Keywords
Cancer Animals
Death Cancer
Decades Drug repurposing
Monoamine Humans
Nervous MAO inhibitors
Molecular Targeted Therapy
Monoamine Oxidase
Monoamine Oxidase
Monoamine oxidase (MAO)
Monoamine Oxidase Inhibitors
Monoamine Oxidase Inhibitors
Neoplasm Proteins
Neoplasm Proteins
Neoplasms

Semantics

Type Source Name
disease MESH cancer
disease MESH cause of death
drug DRUGBANK Hydrogen peroxide
disease MESH tumorigenesis
disease MESH neurodegenerative diseases
pathway REACTOME Neurodegenerative Diseases
disease MESH Parkinson’s disease
disease MESH depression
disease MESH death
drug DRUGBANK Doxorubicin
drug DRUGBANK Bleomycin
drug DRUGBANK Sulfate ion
drug DRUGBANK Dacarbazine
drug DRUGBANK Alpha-1-proteinase inhibitor
disease MESH Breast tumor
drug DRUGBANK Myricetin
drug DRUGBANK Isoniazid
drug DRUGBANK Dopamine
disease MESH Infectious Diseases
disease MESH leukemia
disease MESH Hepatocellular carcinoma
pathway KEGG Hepatocellular carcinoma
disease MESH HNSCC
disease MESH squamous carcinoma
disease MESH shock
drug DRUGBANK Methionine
drug DRUGBANK Sirolimus
disease MESH neuroblastoma
disease MESH NMIBC
drug DRUGBANK Phthalocyanine
pathway KEGG Peroxisome
drug DRUGBANK Oxygen
drug DRUGBANK Vorinostat
drug DRUGBANK Temozolomide
drug DRUGBANK Indoleacetic acid
pathway REACTOME Translation
drug DRUGBANK Serotonin
drug DRUGBANK Epinephrine
drug DRUGBANK Norepinephrine
drug DRUGBANK Phenethylamine
drug DRUGBANK Benzylamine
disease MESH pathogenesis
disease MESH depressive disorders
disease MESH oxidative stress
disease MESH metabolic diseases
disease MESH carcinoma
drug DRUGBANK Ammonia
disease MESH glioma
pathway KEGG Glioma
pathway REACTOME Metabolism
drug DRUGBANK Spinosad
disease MESH Alzheimer’s diseases
drug DRUGBANK Tyramine
disease MESH obesity
disease MESH rheumatoid arthritis
pathway KEGG Rheumatoid arthritis
disease MESH atrophy
pathway REACTOME Apoptosis
disease MESH metastasis
disease MESH hypoxia
disease MESH prostatic hyperplasia
disease MESH adenocarcinoma
drug DRUGBANK Clorgiline
disease MESH prostate cancer
pathway KEGG Prostate cancer
drug DRUGBANK Fenamole
pathway REACTOME Digestion
drug DRUGBANK Trestolone
disease MESH relapse
drug DRUGBANK Enzalutamide
drug DRUGBANK Abiraterone
drug DRUGBANK Apalutamide
drug DRUGBANK Phenelzine
drug DRUGBANK Esomeprazole
pathway REACTOME Autophagy
pathway REACTOME Mitophagy
drug DRUGBANK Docetaxel
drug DRUGBANK Curcumin
drug DRUGBANK Quercetin
drug DRUGBANK Apigenin
drug DRUGBANK Paclitaxel
drug DRUGBANK Selegiline
drug DRUGBANK Cisplatin
drug DRUGBANK Pargyline
drug DRUGBANK L-Phenylalanine
disease MESH syncope
disease MESH urological cancers
pathway REACTOME Glucose metabolism
pathway REACTOME Glycolysis
disease MESH renal carcinomas
drug DRUGBANK Phenobarbital
pathway KEGG Breast cancer
disease MESH chemically induced
disease MESH pituitary tumors
drug DRUGBANK Raloxifene
disease MESH adenoma
disease MESH noma
disease MESH Lung neoplasms
disease MESH lymph node metastases
disease MESH lung adenocarcinoma
pathway REACTOME Fatty acids
drug DRUGBANK Stearic acid
drug DRUGBANK Staurosporine
drug DRUGBANK ATP
drug DRUGBANK L-Tyrosine
disease MESH primary brain tumor
disease MESH glioblastoma
pathway REACTOME M Phase
drug DRUGBANK Sulodexide
disease MESH tumor immune evasion
disease MESH Hematological malignancies
drug DRUGBANK L-Leucine
disease MESH lymphomas
drug DRUGBANK Methyprylon
disease MESH Hodgkin lymphoma
disease MESH Adrenal cortical carcinoma
disease MESH tic
disease MESH melanoma
pathway KEGG Melanoma
drug DRUGBANK Coenzyme M
disease MESH cutaneous malignant melanoma
disease MESH neuroendocrine tumor
disease MESH malignant pleural mesothelioma
disease MESH intestinal neoplasms
drug DRUGBANK Pidolic Acid
disease MESH hyperplasia
drug DRUGBANK Tranylcypromine
disease MESH Infection
disease MESH gastric cancer
pathway KEGG Gastric cancer
disease MESH inflammation
drug DRUGBANK Nitazoxanide
disease MESH esophageal cancer
disease MESH cholangiocarcinoma
pathway REACTOME Acetylation
disease MESH Otorhinolaryngologic neoplasms
disease MESH Nasopharyngeal carcinoma
disease MESH EBV infection
pathway REACTOME Methylation
disease MESH pharynx cancers
disease MESH endometrial carcinoma
disease MESH pheochromocytoma
pathway REACTOME Reproduction
drug DRUGBANK Nonoxynol-9
disease MESH CNS diseases
drug DRUGBANK Iron
drug DRUGBANK Metformin
drug DRUGBANK Empagliflozin
drug DRUGBANK Dapagliflozin
disease MESH colorectal cancer
pathway KEGG Colorectal cancer
drug DRUGBANK (S)-Des-Me-Ampa
drug DRUGBANK Troleandomycin
drug DRUGBANK Isocarboxazid
disease MESH treatment resistant depression
disease MESH drug interactions
drug DRUGBANK Dextrose unspecified form
disease MESH bladder cancer
pathway KEGG Bladder cancer
drug DRUGBANK BCG vaccine
drug DRUGBANK Isosorbide Mononitrate
drug DRUGBANK Dimethyl sulfone
drug DRUGBANK Guanosine
disease MESH neurological disorders
drug DRUGBANK Butoconazole
disease MESH acute lymphoblastic Leukemia
disease MESH polyps
drug DRUGBANK Naproxen
disease MESH oral cancer
disease MESH asthma
pathway KEGG Asthma

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