Publication date: May 22, 2025
In pooled analyses of placebo- controlled trials of antidepressants, the incidence of suicidal thoughts and behaviors in antidepressant-treated patients ages 24 and younger was greater than in placebo-treated patients. Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients in short-term studies. In male patients, serotonergic antidepressant use may result in ejaculatory delay or failure, decreased libido, and erectile dysfunction. Elderly patients and patients taking diuretics or who are otherwise volume-depleted can be at greater risk. Consider changing the therapeutic regimen, including possibly discontinuing TRINTELLIX, in patients whose depression is persistently worse, or who are experiencing emergence of suicidal thoughts and behaviors. Inform patients about the increased risk of bleeding when TRINTELLIX is co administered with NSAIDs, aspirin, or other drugs that affect coagulation or bleeding. Through my experience with patients, Ive discussed several different treatment options, including Trintellix, also known as vortioxetine, a prescription medication indicated to treat MDD in adults.