Publication date: May 23, 2025
In addition, the researchers validated site-specific methylation using electron microscopy-amplicon sequencing. The study revealed extensive changes to DNA methylation in the DR genomic regions. Researchers from Japan have now identified RABGGTB as a novel autism-linked gene during DNA methylation mapping in the dorsal raphe nuclei of the brain. Further, hypomethylation was observed in the RABGGTB promoter region a gene related to autophagy and synaptic function which corresponded to its heightened expression. RABGGTB is an exciting discovery. DNA methylation profiles of the DR in the context of ASD have not previously been investigated.
Semantics
| Type | Source | Name |
|---|---|---|
| pathway | REACTOME | DNA methylation |
| disease | MESH | autism |
| drug | DRUGBANK | Sulfasalazine |
| drug | DRUGBANK | Serotonin |
| pathway | REACTOME | Methylation |
| pathway | REACTOME | Autophagy |
Original Article
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