Publication date: Jun 11, 2025
To examine the brain morphological characteristics of 2-to-4-year-olds with ASD, including cortical and subcortical regions, and to investigate their associations with clinical behaviors. A total of 43 toddlers with ASD aged 2-4 years, 44 age- and gender- matched toddlers with developmental delay (DD) and 18 typically developing (TD) children were recruited. All participants underwent whole-brain high-resolution MRI and clinical assessments. Brain structural data were analyzed using Surface-Based Morphometry with FreeSurfer. Linear mixed-effects models were employed to identify differences in brain regions between groups and to explore their links with clinical behaviors. Compared to TD group, ASD group demonstrated increased cortical thickness and volume, particularly within the frontal and parietal brain regions (FDR, p
| Concepts | Keywords |
|---|---|
| Autism | Autism Spectrum Disorder |
| Freesurfer | Brain Morphology |
| Mri | Cortical Thickness |
| Toddlers | Cortical Volume |
| Years | Magnetic Resonance Imaging |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Autism Spectrum Disorder |
| disease | MESH | Abnormalities |