Publication date: Jun 23, 2025
Credit: Wikipedia commonsResearchers have discovered that the most aggressive melanomas, the deadliest form of skin cancer, overactivate two key processes in mitochondria, the components of cells that provide energy. Two types of drugs accomplished this: antibioticsoriginally designed to block bacterial protein synthesis machinery, which closely resembles the machinery found in mitochondriaand specialized energy-production inhibitors. “By pairing mitochondrial blockers with today’s standards of care, we may cut off a major escape route that cancers use to resist therapy and come back. “Dr. Importantly, non-cancerous skin cells remained mostly unaffected, highlighting the safety and specificity of these treatment approaches. Editors have highlighted the following attributes while ensuring the content’s credibility:Mitochondria. This article has been reviewed according to Science X’s editorial process and policies . DOI: 10. 1002/cncr. 35897 Journal information: Cancer
| Concepts | Keywords |
|---|---|
| Biology | Aggressive |
| Cancerous | Blocking |
| Kill | Cancer |
| Wikipedia | Cancers |
| Discovered | |
| Drugs | |
| Energy | |
| Inhibitors | |
| Machinery | |
| Melanoma | |
| Melanomas | |
| Mitochondria | |
| Mitochondrial | |
| Pathways | |
| Skin |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | melanoma |
| pathway | KEGG | Melanoma |
| disease | MESH | skin cancer |
| disease | MESH | Cancer |
| drug | DRUGBANK | Spinosad |
| drug | DRUGBANK | Nonoxynol-9 |